Measuring semantic similarities by combining gene ontology annotations and gene co-function networks
نویسندگان
چکیده
منابع مشابه
Measuring semantic similarity between Gene Ontology terms
Many bioinformatics applications would benefit from comparing proteins based on their biological role rather than their sequence. This manuscript adds two new contributions. First, a study of the correlation between Gene Ontology (GO) terms and family similarity demonstrates that protein families constitute an appropriate baseline for validating GO similarity. Secondly, we introduce GraSM, a no...
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Contemporary techniques in biology produce readouts for large numbers of genes simultaneously, the typical example being differential gene expression measurements. Moreover, those genes are often richly annotated using GO terms that describe gene function and that can be used to summarize the results of the genome-scale experiments. However, making sense of such GO enrichment analyses may be ch...
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The Gene Ontology (GO) Consortium (GOC, http://www.geneontology.org) is a community-based bioinformatics resource that classifies gene product function through the use of structured, controlled vocabularies. Over the past year, the GOC has implemented several processes to increase the quantity, quality and specificity of GO annotations. First, the number of manual, literature-based annotations ...
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MOTIVATION Ontologies such as the Gene Ontology (GO) and their use in annotations make cross species comparisons of genes possible, along with a wide range of other analytical activities. The bio-ontologies community, in particular the Open Biomedical Ontologies (OBO) community, have provided many other ontologies and an increasingly large volume of annotations of gene products that can be expl...
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Careful examination of the existing evidence underpins formulation of novel hypotheses and experimental design. However, each year the state of the ground truth becomes more difficult to approximate due to the rapid proliferation of primary literature and associated databases. With over a million new articles added to MEDLINE annually, mastering even the subfield literature has become difficult...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2015
ISSN: 1471-2105
DOI: 10.1186/s12859-015-0474-7